Side Effects of PrEP: What You Need to Know

Starting PrEP (pre-exposure prophylaxis) is an important step in protecting your health. If you’re considering it (or have recently started) you might be wondering what to expect, especially when it comes to side effects.

It’s completely normal to have questions. The goal isn’t to create worry, but to help you feel informed, supported, and more at ease in your decision.

What Is PrEP?

PrEP is a daily medication used to help prevent HIV. When taken consistently, it is highly effective in reducing the risk of HIV transmission.

Like any medication, PrEP can come with side effects— but for many people, these are mild and temporary.

Common Side Effects of PrEP

Some people experience side effects when first starting PrEP, especially in the first few weeks as the body adjusts.

These may include:

• Nausea

• Mild stomach discomfort

• Headaches

• Fatigue

• Changes in appetite

These symptoms are often temporary and tend to improve as your body gets used to the medication.

If side effects feel persistent or uncomfortable, it’s always okay to check in with your healthcare provider.

Digestive Changes and How to Support Your Body

Because some of the more common side effects involve the digestive system, it can be helpful to think about how HIV diet and nutrition measures can support your body during this time.

If you’re experiencing nausea or GI discomfort, small adjustments can help:

• Eating smaller, more frequent meals

• Choosing easy-to-digest foods

• Staying hydrated throughout the day

• Avoiding long gaps between meals

Nutrition doesn’t have to be complicated, it can simply be about finding what feels manageable and supportive as your body adjusts.

Longer-Term Considerations

For most people, PrEP is well tolerated long term.

In some cases, providers may monitor:

• Kidney function

• Bone health

This is part of routine care and helps ensure that PrEP continues to be a safe and effective option for you.

Regular check-ins with your healthcare provider are an important part of ongoing support.

You Don’t Have to Push Through Discomfort

If something doesn’t feel right, it’s okay to speak up.

You deserve care that feels supportive— not something you have to tolerate in silence. Whether side effects are mild or more noticeable, your experience matters.

Sometimes, small adjustments in routine, timing, or nutrition can make a meaningful difference.

How a Dietitian Can Help

If you’re experiencing side effects that impact your eating or digestion, working with a dietitian can help you find ways to support your body in a realistic and manageable way.

This might include:

• Adjusting meal timing or composition

• Supporting digestion during medication adjustments

• Maintaining consistent nourishment even when appetite is low

• Helping you feel more confident in your HIV diet and nutrition approach

You don’t have to navigate these changes alone.

Support That Meets You Where You Are

At Couture Wellness, we provide compassionate, individualized support for those navigating HIV diet and nutrition, including individuals taking PrEP.

We understand that your experience with food, health, and medication is personal—and our goal is to help you feel supported, informed, and cared for every step of the way.

If you have questions or are looking for guidance, you’re always welcome to reach out or book with our team.